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Oral nutritional formulation containing 10 amino acids ; provides all essential amino acids five out of them are keto or hydroxyanalogues that help in reducing Nitrogen load while it promotes muscle protein synthesis.
Alpha-keto analogues are beneficial in treatment of uremia as they provide adequate amino acid nutrition while reducing the total nitrogen load; these analogues are converted to amino-acids through transamination by taking amino group from nonessential amino acids and thereby reducing cellular ammonia level.
Adding Ketoanalogue to very low-protein ( 40 g per day) diets for patients with chronic kidney disease (CKD stage I,II,III), generally in patients with glomerular filtration rate (GFR) less than 25ml/min., significantly reduces the progression of kidney disease in the predialysis period and delays dialysis initiation.
Used for Prevention and Treatment of deficient protein metabolism in chronic renal insufficiency.