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Menthol is used in the treatment of dermatitis, itching and eczema.
Menthol primarily activates the cold-sensitive TRPM8 receptors in the skin. Menthol, after topical application, causes a feeling of coolness due to stimulation of 'cold' receptors by inhibiting Ca++ currents of neuronal membranes. It may also yield analgesic properties via kappa-opioid receptor agonism.
Balance disorder (loss of balance), Vomiting, Altered heart rate, Drowsiness, Hypersensitivity reaction, Nausea, Abdominal pain, Contact dermatitis, Skin irritation, Apnea (absence of breathing), Nystagmus (involuntary eye movement), Vertigo, Coma.
Methyl Salicylate is used in musculo-skeletal pain, dental pain and post operative pain.
Methyl salicylate is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the release of prostaglandin, that causes allergy symptoms and inflammation (swelling and redness).
Thiocolchicoside topical is used as an additive in the treatment of painful stiffness or constriction in muscular disorders. .
Thiocolchicoside topical is a muscle relaxant. It works by relieving pain and discomfort caused by strains, sprains, and other muscle injuries.